Enabling intelligent therapies with
conditionally active biologics
Redefining Conditionally Active Biologics
We create conditionally active multispecific biologics with high therapeutic index designed to reach difficult-to-treat targets
We address unmet need in complex therapeutic areas
Persistent Industry Problems
Validated therapeutic pathway, but non-conditional targeting results in pleiotropic activity, systemic toxicity and low therapeutic index
Difficult-to-make cytokines and proteins remain elusive due to stability and expression hurdles
Our Proprietary Platform’s Solution
VH-Select™
Stabilized fully human VH scaffold for binder discovery that overcomes expression challenges and enables previously unattainable potent biological activity
FunctionSeq™
Mammalian display combined with NGS screening identifies conditional multispecifics from libraries of 10⁴ - 10⁵ molecules, ensuring precise activation restricted to the targeted cell
Our unique VH-Select™ and FunctionSeq™ technologies enables us to leverage validated biology to create highly differentiated therapies in oncology (including immuno-oncology), autoimmune disease and beyond.
